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Turmeric extract alleviates airway inflammation via oxidative stress-driven MAPKs/MMPs pathway. | LitMetric

Turmeric extract alleviates airway inflammation via oxidative stress-driven MAPKs/MMPs pathway.

Int Immunopharmacol

College of Veterinary Medicine (BK21 FOUR Program), Chungnam National University, 99 Daehak-ro, Daejeon 34131, Republic of Korea. Electronic address:

Published: November 2024

AI Article Synopsis

  • Turmeric extract (CLE) has demonstrated significant anti-inflammatory effects and is traditionally used in Asian medicine, prompting research on its impact on airway inflammation, particularly in asthma.
  • In a study with asthmatic mice and human airway cells (A549), CLE was found to reduce eosinophil counts, cytokine levels, and oxidative stress, indicating its efficacy in managing airway inflammation.
  • The mechanism involves the suppression of specific signaling pathways, namely MAPK/MMPs, suggesting that CLE could be a promising treatment for asthma patients.

Article Abstract

Turmeric (Curcuma longa L.) extract (CLE) has been shown to elicit several pharmacological properties and is widely used in Asian traditional medicine. Herein, we assessed the impact of CLE on airway inflammation in BALB/c mice and A549 cells to clarify the underlying mechanism. An asthmatic mouse model was established by administering ovalbumin (OVA). CLE (100 or 300 mg/kg/day) was orally administered daily from days 18 to 23, with dexamethasone (3 mg/kg/day) used as the positive control. Human airway epithelial cells, A549, were stimulated using recombinant tumor necrosis factor-α. The CLE100 and CLE400 groups exhibited a significant downregulation in eosinophil counts, cytokine levels, and immunoglobulin-E levels. Moreover, CLE administration dose-dependently suppressed oxidative stress and airway inflammation in the lung tissue. CLE administration inhibited the phosphorylation of mitogen-activated protein kinases (MAPKs) and the expression and activity of matrix metalloproteinase (MMP)-9. In vitro, CLE treatment reduced mRNA levels of proinflammatory cytokines, MAPK phosphorylation, and the expression and activity of MMP-2 and MMP-9. Additionally, 50 µg/mL CLE and 2.5 µg/mL curcumin showed similar anti-inflammatory effects. Collectively, our findings revealed that CLE could suppress airway inflammation in asthmatic mice and A549 cells via oxidative stress-driven MAPK/MMPs signaling, suggesting that CLE could be developed as a potential treatment option for patients with asthma.

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Source
http://dx.doi.org/10.1016/j.intimp.2024.113018DOI Listing

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