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Modified Gallie's (Sonntag) Posterior Wiring Technique Supplemented With Goel-Harms C1-C2 Fixation For Pediatric Craniovertebral Junction Anomaly.
Neurol India
July 2024
Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.
Sonntag procedure in Atlanto-odontoid fractures type III in restoring Atlanto-axial complex stability: A case report.
Int J Surg Case Rep
September 2023
Department of Orthopaedics and Traumatology, Dr. Cipto Mangunkusumo General Hospital - Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.
Introduction And Importance: Fractures of the second cervical vertebrae (C2) and its odontoid process account for one of the most frequent cervical spine injuries that cause significant mortality and morbidity. The goal of injury treatment is to restore atlantoaxial complex stability. This article reports a young male patient aged 19 years who underwent surgical treatment due to odontoid fractures type III.
View Article and Find Full Text PDFThe layered costs and benefits of translational redundancy.
Elife
March 2023
National Centre for Biological Sciences (NCBS-TIFR), Bengaluru, India.
The rate and accuracy of translation hinges upon multiple components - including transfer RNA (tRNA) pools, tRNA modifying enzymes, and rRNA molecules - many of which are redundant in terms of gene copy number or function. It has been hypothesized that the redundancy evolves under selection, driven by its impacts on growth rate. However, we lack empirical measurements of the fitness costs and benefits of redundancy, and we have poor a understanding of how this redundancy is organized across components.
View Article and Find Full Text PDFHost-parasite coevolution promotes innovation through deformations in fitness landscapes.
Elife
July 2022
Department of Ecology, Behavior and Evolution, University of California San Diego, La Jolla, United States.
During the struggle for survival, populations occasionally evolve new functions that give them access to untapped ecological opportunities. Theory suggests that coevolution between species can promote the evolution of such innovations by deforming fitness landscapes in ways that open new adaptive pathways. We directly tested this idea by using high-throughput gene editing-phenotyping technology (MAGE-Seq) to measure the fitness landscape of a virus, bacteriophage λ, as it coevolved with its host, the bacterium .
View Article and Find Full Text PDFBackground: Stratifying risk of postoperative pulmonary complications after major abdominal surgery allows clinicians to modify risk through targeted interventions and enhanced monitoring. In this study, we aimed to identify and validate prognostic models against a new consensus definition of postoperative pulmonary complications.
Methods: We did a systematic review and international external validation cohort study.
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