AI Article Synopsis
- This study introduces formate salt as a new bifunctional reagent that can synthesize phenol derivatives and produce carbon monoxide (CO) for cross-coupling reactions.
- The process employs an innovative nickel/organophotocatalyst system under blue LED light to generate aryl formate, which is crucial for the reactions.
- The findings show that commercially available HCOONa (sodium formate) can effectively be used in various reactions involving aryl iodides and carbonylative processes.
Article Abstract
In this study, we disclose for the first time that formate salt can be used as a bifunctional reagent for the synthesis of phenol derivatives and as a CO source for carbonylative cross-coupling processes using the COware gas reactor under activation free conditions. Key to this success is the in-situ synthesis of aryl formate via an unprecedented nickel/organophotocatalyst system under blue LED irradiation. This developed system demonstrated high applicability to various aryl iodide substrates for synthesizing phenol derivatives. Moreover, the generated CO could be utilized in a range of carbonylative C-heteroatom and C-C processes. Notably, commercially available HCOONa salt can serve as a bifunctional reagent for both synthesizing phenols and generating CO.
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| http://dx.doi.org/10.1002/chem.202403221 | DOI Listing |
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