To investigate the clinical features, diagnosis and treatment of lymphoepithelioma-like carcinoma (LELC). The clinical data of 114 LELC patients were retrospectively analyzed. Ninety-eight patients (86.0%) were Epstein-Barr virus-encoded small RNA (EBER) positive detected by situ hybridization. A 67.1% (51/76) patients had PD-L1 expression. The 5-year overall survival rate of EBER negative patients was 51.6% while the rate of positive patients was 84.8% ( = 0.015). The 5-year progression free survival rate of EBER negative patients was 40.2% while the rate of positive patients was 70.2% ( = 0.004). The progression of LELC is relatively slow and present a better prognosis. The occurrence of tumor is closely related to Epstein-Barr virus infection and PD-L1 is highly expressed in tumor cells.
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| http://dx.doi.org/10.1080/20565623.2024.2384878 | DOI Listing |
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