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Adjunctive PCSK9 Inhibitor Evolocumab in the Prevention of Early Neurological Deterioration in Non-cardiogenic Acute Ischemic Stroke: A Multicenter, Prospective, Randomized, Open-Label, Clinical Trial.
CNS Drugs
January 2025
Department of Cardiology, Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Background: Early neurological deterioration (END) is associated with a poor prognosis in acute ischemic stroke (AIS). Effectively lowering low-density lipoprotein cholesterol (LDL-C) can improve the stability of atherosclerotic plaque and reduce post-stroke inflammation, which may be an effective means to lower the incidence of END. The objective of this study was to determine the preventive effects of evolocumab on END in patients with non-cardiogenic AIS.
View Article and Find Full Text PDFSoft grid integration control strategy for self synchronized voltage source DFIG wind turbine generator.
Sci Rep
January 2025
School of Electrical Engineering, Nanjing Vocational University of Industry Technology, Nanjing, 210023, China.
Transitioning to a power system heavily reliant on renewable wind energy involves more than just replacing conventional fossil-fuel-based power plant with wind farms, the wind energy must be able to meet the requirement of voltage establishment and power balance. It is believed that the self synchronized voltage source control of DFIG wind turbine generator is one of the possible solutions to realize virtual inertia and is helpful to increase the frequency stability of power system, thus is meaningful in the transformation of the power system dominated by renewable energy. Plenty of research has been conducted on the self synchronized voltage source control strategy in steady state, but few research is focused on the soft grid integration, which is a complicated process involving wind turbine control and power converter control.
View Article and Find Full Text PDFEnhancement of quantum synchronization in triple-cavity system.
Sci Rep
January 2025
School of Physics and Optoelectronics, Xiangtan University, Xiangtan, 411105, China.
We introduce two strategies to enhance quantum synchronization within a triple-cavity optomechanical system, where each cavity contains an oscillator and is interconnected via optical fibers. Our results demonstrate that applying appropriate periodic modulation to the driving fields or the cavity modes can ensure robust quantum synchronization across both open and closed configurations. This approach offers promising avenues for expanding quantum synchronization capabilities in multi-cavity systems and has significant implications for advancing quantum synchronization generation and application in complex networks.
View Article and Find Full Text PDFModeling and analysis of explicit dynamics of foot landing.
Med Biol Eng Comput
January 2025
School of Medical Engineering, Department of Cardiology of The First Affiliated Hospital of Xinxiang Medical University, Xinxiang Medical University, Xinxiang, 453003, Henan, China.
The research aims to investigate the mechanical response of footfalls at different velocities to understand the mechanism of heel injury and provide a scientific basis for the prevention and treatment of heel fractures. A three-dimensional solid model of foot drop was constructed using anatomical structures segmented from medical CT scans, including bone, cartilage, ligaments, plantar fascia, and soft tissues, and the impact velocities of the foot were set to be 2 m/s, 4 m/s, 6 m/s, 8 m/s, and 10 m/s. Explicit kinetic analysis methods were used to investigate the mechanical response of the foot landing with different speeds to explore the damage mechanism of heel bone at different impact velocities.
View Article and Find Full Text PDFA preliminary exploration of establishing a mice model of hypoxic training.
Sci Rep
January 2025
Institute of Brain Diseases and Cognition, School of Medicine, Xiamen University, Xiamen, 361102, Fujian, China.
Altitude training has been widely adopted. This study aimed to establish a mice model to determine the time point for achieving the best endurance at the lowland. C57BL/6 and BALB/c male mice were used to establish a mice model of hypoxic training with normoxic training mice, hypoxic mice, and normoxic mice as controls.
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