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http://dx.doi.org/10.1016/j.cpet.2024.07.001 | DOI Listing |
Cardiovasc Diagn Ther
December 2024
Operational Research Center in Healthcare, Near East University, Nicosia, Turkey.
Background: Cardiovascular diseases (CVDs) continue to be the world's greatest cause of death. To evaluate heart function and diagnose coronary artery disease (CAD), myocardial perfusion imaging (MPI) has become essential. Artificial intelligence (AI) methods have been incorporated into diagnostic methods such as MPI to improve patient outcomes in recent years.
View Article and Find Full Text PDFJ Neurosci
January 2025
German Center for Neurodegenerative Diseases (DZNE), Magdeburg 39120, Germany
The precuneus is a site of early amyloid-beta (Aβ) accumulation. Previous cross-sectional studies reported increased precuneus fMRI activity in older adults with mild cognitive deficits or elevated Aβ. However, longitudinal studies in early Alzheimer's disease (AD) are lacking and the relationship to the Apolipoprotein-E () genotype is unclear.
View Article and Find Full Text PDFClin Nucl Med
December 2024
From the NanFang PET Center, NanFang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China.
We report a rare case of eosinophilic gastrointestinal disorders in a 60-year-old woman, which extensively involved the digestive tract from the esophagus, gastric, duodenum to the small intestine, depicted well by 18F-FAPI-42 PET/CT, superior to 18F-FDG PET/CT. Under the guidance of 18F-FAPI-42 PET/CT, the biopsy was successfully performed, and the diagnosis was established. This case highlights that 18F-FAPI-42 PET/CT may serve as a novel noninvasive method for evaluating eosinophilic gastrointestinal disorders.
View Article and Find Full Text PDFClin Transl Gastroenterol
December 2024
Department of Radiation Oncology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
Introduction: Gastric cancer (GC) is a leading cause of cancer-related deaths worldwide, with delayed diagnosis often limiting effective treatment options. This study introduces a novel, non-invasive radiomics-based approach utilizing [18F] FDG PET/CT to predict VEGF status and survival in GC patients. The ability to non-invasively assess these parameters can significantly influence therapeutic decisions and outcomes.
View Article and Find Full Text PDFAnal Chem
January 2025
Department of Chemistry, Chung-Ang University, Seoul 06974, South Korea.
Reductase expression is a potential indicator of cellular pathology. Single-detection systems for reductases have been developed, however, the development of dual-detection systems remain largely unexplored. We rationally designed a dual-lock fluorescent probe that exhibited a high signal-to-noise ratio with a fluorescence Off-On response exclusively for the simultaneous activity of two reductases, NTR and hNQO1, which are overexpressed in cancer hypoxia.
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