AI Article Synopsis
- Acute generalised exanthematous pustulosis (AGEP) is a rare skin condition characterized by small, non-follicular pustules on red, swollen skin, often triggered by medications, particularly antibiotics.
- The case presented discusses AGEP triggered by the medication bupropion and a subsequent occurrence alongside a herpes simplex virus (HSV) infection, suggesting an overlap between the two conditions.
- This case highlights the challenge of distinguishing between AGEP and disseminated HSV due to their similar symptoms, raising important questions about treatment options, particularly the risks versus benefits of using systemic steroids.
Article Abstract
Acute generalised exanthematous pustulosis (AGEP) is a rare cutaneous disorder that presents with numerous non-follicular, pinpoint sterile pustules on a background of oedematous erythema that can coalesce, leading to desquamation. 90% of cases are triggered by medications, most often with antibiotics as the culprit. However, other triggers including viral infection have also been reported. Herpes simplex virus (HSV) as a viral trigger has not been previously explored. Here, we present a case of AGEP caused by bupropion, followed by a second presentation of assumed acute limited exanthematous pustulosis in the setting of disseminated HSV. This case may represent the first report of AGEP and HSV overlap. It also presents the interesting dilemma of differentiating AGEP and disseminated HSV (which can present similarly) as well as determining appropriate treatment and the utility versus risk of systemic steroid administration.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1136/bcr-2024-260873 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Vancomycin-induced acute generalised exanthematous pustulosis.
BMJ Case Rep
January 2025
Western Michigan University Homer Stryker MD School of Medicine, Kalamazoo, Michigan, USA.
Antibiotics have been well documented to result in several dermatological adverse reactions. Many of these adverse reactions are rashes that are difficult to distinguish. We present a case of a female patient in her 30s with acute generalised exanthematous pustulosis following vancomycin treatment for left breast cellulitis.
View Article and Find Full Text PDFDiffuse pustules overlying brightly erythematous plaques in skin of color.
JAAD Case Rep
February 2025
Harvard Medical School, Boston, Massachusetts.
Unusual Presentation of Acute Generalized Exanthematous Pustulosis with Unilateral Anterior Trunk Involvement.
Sisli Etfal Hastan Tip Bul
December 2024
Department of Pathology, University of Health Sciences Türkiye, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Türkiye.
Acute generalized exanthematous pustulosis (AGEP) is a rare drug eruption characterized by the rapid occurrence of many sterile, non-follicular pustules, neutrophilic leukocytosis, high fever and spontaneous resolution usually within two weeks. The distribution of rash predilection in the trunk and intertriginous regions. In treatment, the causative drug must be initially discontinued.
View Article and Find Full Text PDFRecurrent pediatric acute generalized exanthematous pustulosis with drug and infective precipitants.
JAAD Case Rep
January 2025
Department of Dermatology, National University Hospital, Singapore.
Acute generalized exanthematous pustulosis is a severe cutaneous adverse reaction characterized by the rapid onset of nonfollicular, sterile pustules on an erythematous base, typically accompanied by fever (≥38 °C), neutrophilia (7.0 × 10⁹/L), and characteristic histopathological features. This case report presents the first documented instance of acute generalized exanthematous pustulosis after hyaluronic acid viscosupplementation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!