AI Article Synopsis
- Researchers developed cholinized-polymer functionalized lipid-based nanoparticles (CP-LNPs) that deliver drugs to the liver quickly and effectively, with targeting achieved in just 10 minutes and near-perfect efficiency.
- The CP-LNPs loaded with curcumin, an antifibrotic agent, improved its stability and liver distribution, and were shown to reduce harmful cell activity and oxidative stress in liver cells.
- In animal studies, low doses of CP-LNPs/Cur significantly reduced liver injury and prevented fibrosis progression, highlighting their potential in treating liver conditions.
Article Abstract
Here, we report novel cholinized-polymer functionalized lipid-based nanoparticles (CP-LNPs) for rapid and highly effective delivery of drugs to the liver, achieving targeting within 10 min and nearly 100% efficiency. In this study, CP-LNPs loaded with a promising antifibrotic agent curcumin (CP-LNPs/Cur) significantly improved the stability of curcumin under physiological conditions and its distribution in the liver. In vitro experiments demonstrated that CP-LNPs/Cur effectively suppressed the proliferation and migration of activated hepatic stellate cells (aHSCs), as evidenced by the decreased expression of α-SMA. Moreover, CP-LNPs/Cur attenuated oxidative stress levels in hepatocytes while improving mitochondrial physiological activity. In vivo antifibrosis studies have shown that CP-LNPs/Cur only require a low dose to significantly alleviate liver injury and collagen deposition, thereby preventing the progression of liver fibrosis. These findings indicated that CP-LNPs exhibit great potential in liver fibrosis therapy benefiting from the novel targeting strategy.
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| http://dx.doi.org/10.1021/acs.biomac.4c00691 | DOI Listing |
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