AI Article Synopsis
- * This type of cancer is particularly deadly because it tends to show symptoms late and spreads quickly through lymph nodes or blood to other areas, including direct invasion of the liver.
- * While surgery can potentially cure GBC in its early stages, treatment options are mostly ineffective for patients with more advanced disease.
Article Abstract
Gallbladder carcinoma (GBC) is the most common biliary epithelial malignancy, with an estimated incidence of 1.13 cases per 100,000 in the United States (Hundal and Shaffer in Clin Epidemiol 6:99-109, 2014 1; Henley et al. in Cancer Epidemiol Biomarkers Prev 24:1319-1326, 2015 2). The insidious nature and late presentation of this disease place it among the most lethal invasive neoplasms. Gallbladder cancer spreads early by lymphatic or hematogenous metastasis, as well as by direct invasion into the liver. While surgery may be curative at early stages, both surgical and nonsurgical treatments remain largely unsuccessful in patients with more advanced diseases (Rahman et al. in Cancer Med 6:874-880, 2017 3).
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| http://dx.doi.org/10.1007/978-3-031-61238-1_8 | DOI Listing |
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