AI Article Synopsis
- - The study analyzed clinical data from 112 penile cancer patients treated at Weifang People's Hospital between 2013 and 2023 to identify risk factors impacting cancer-specific survival (CSS) post-surgery.
- - Results showed that the 1-, 3-, and 5-year CSS rates were 78.2%, 66.1%, and 63.7%, respectively, with a higher neutrophil-to-lymphocyte ratio (NLR) significantly linked to lower CSS rates.
- - Key independent risk factors for poor prognosis included high NLR, older age, occupation type (farmer or worker), lower education, and certain preoperative blood ratio and fibrinogen levels.
Article Abstract
Objective: To investigate the risk factors affecting the prognosis of penile cancer after surgery.
Methods: We retrospectively analyzed the clinical data on 112 cases of penile cancer treated in Weifang People's Hospital from January 2013 to December 2023. Using the Kaplan-Meier survival curve, χ2 test, Fisher's exact test, and univariate and multivariate Cox risk regression analyses, we compared the clinical characteristics among different groups, and determined the independent prognostic risk factors for cancer-specific survival (CSS) of the patients.
Results: The 1-, 3- and 5-year CSS rates of the penile cancer patients were 78.2%, 66.1% and 63.7%, respectively. Kaplan-Meier analysis indicated a significant correlation of a higher neutrophil-to-lymphocyte ratio (NLR) with a lower CSS rate (P < 0.001). Multivariate Cox regression analysis showed high NLR (HR = 2.6; 95% CI: 1.031－6.558; P = 0.043) to be an independent risk factor for CSS.
Conclusion: Preoperative NLR is an independent risk factor for the prognosis of penile cancer. In addition, older age, farmer or worker occupation, lower education, preoperative lymphocyte-to-monocyte ratio (LMR)≤2.81, preoperative fibrinogen (FIB)≥3.41 g/L, advanced tumor stage and tumor differentiation are associated with the poor prognosis the malignancy.
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