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Lactulose use among patients with alcohol-related liver cirrhosis as a surrogate marker of hepatic encephalopathy: prevalence and association with mortality - a Danish nationwide cohort study.
Metab Brain Dis
January 2025
Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus N, Denmark.
Background & Aims: Hepatic encephalopathy (HE), one of the most serious prognostic factors for mortality in alcohol-related cirrhosis (ALD cirrhosis), is not recorded in Danish healthcare registries. However, treatment of HE with lactulose, the universal first-line treatment, can be identified through data on filled prescriptions. This study aimed to investigate if lactulose can be used as a surrogate marker of HE.
View Article and Find Full Text PDFIncidence and outcomes of neonatal group B streptococcal sepsis in Qatar-a multicentre study.
BMC Pediatr
January 2025
Department of Neonatology, Al Wakra Hospital, Hamad Medical Corporation, Doha, Qatar.
Background: Group B Streptococcus (GBS) is the most common cause of neonatal early onset sepsis in term infants and a major cause of late onset sepsis in both term and preterm infants.
Aim: To estimate the incidence of GBSS among neonates born in Qatar between July 2015 and June 2020 (5 years). A secondary aim was to describe the outcomes of the affected babies.
A novel Schirmer Strip-Based Tear Matrix Metalloproteinase Measurement in Dry Eye Evaluation.
Ocul Surf
January 2025
Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences; Key Laboratory of Ocular Fundus Diseases, Chinese Academy of Medical Sciences. Electronic address:
Unlabelled: Dry eye disease is a multifactorial disorder of the ocular surface with increasing global prevalence, yet no universally accepted "gold standard" exists for its diagnosis or severity assessment. Tear matrix metalloproteinase 9 (MMP-9) is widely recognized as a valuable biomarker for dry eye, yet there remains a critical need for a simple, accurate, and broadly applicable method for its quantification. This study aims to develop and evaluate a Schirmer strip-based Eu-time resolved fluorescence immunochromatography (Eu-TRFICO) method for the quantitative detection of MMP-9 in tears.
View Article and Find Full Text PDFAn expanding universe of mutational signatures and its rapid evolution in single-stranded RNA viruses.
Mol Biol Evol
January 2025
Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
The study of mutational processes in somatic genomes has gained recent momentum, uncovering a wide array of endogenous and exogenous factors associated with somatic changes. However, the overall landscape of mutational processes in germline mutations across the tree of life and associated evolutionary driving forces are rather unclear. In this study, we analyzed mutational processes in single-stranded RNA (ssRNA) viruses which are known to jump between different hosts with divergent exogenous environments.
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