Diabetic gastroparesis, a common complication of type 2 diabetes (T2DM), presents a significant treatment challenge. is emerging as a potential therapy. is a traditional Chinese medicine formula with the potential for treating diabetic gastroparesis by modulating gut microbiota and cAMP/PKA signaling pathways. This study explores the mechanisms behind 's effects on T2DM-induced gastroparesis, focusing on its impact on gut microbiota and the cAMP/PKA pathway. A rat model of type 2 diabetic gastroparesis was established through a high-fat diet and streptozotocin (STZ) injection, and the effects of were assessed. Additionally, protein expression related to the cAMP/PKA pathway was examined, and 's influence on gut microbiota was studied using 16S rRNA sequencing. significantly alleviated hyperglycemia, improved gastric pathology in rats with gastroparesis, enhanced the expression of 5-HT4, cAMP, PKA, and pPKA in the gastric antrum, and rebalanced gut microbiota. demonstrates the therapeutic potential for T2DM-associated gastroparesis by modulating the cAMP/PKA pathway and gut microbiota.
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| http://dx.doi.org/10.1016/j.heliyon.2024.e35558 | DOI Listing |
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