AI Article Synopsis
- Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, with HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) making up 70% of OPSCC cases.
- High-risk HPV infections are associated with cancer, but HPV alone doesn't cause it; there’s a need for further research on how HPV interacts with the human microbiome.
- This review focuses on the changes in the oropharyngeal microbiome linked to HPV-positive OPSCC and explores potential interactions between HPV and certain microorganisms, highlighting the necessity of more studies in this area.
Article Abstract
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer globally. Notably, human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is on the rise, accounting for 70% of all OPSCC cases. Persistent high-risk HPV infection is linked to various cancers, but HPV infection alone is not sufficient to cause cancer. Advances in next-generation sequencing have improved our understanding of changes in the human microbiome of cancerous environments. Yet, there remains a dearth of knowledge on the impact of HPV-microbiome crosstalk in HPV-positive OPSCC. In this review, we examine what is known about the oropharyngeal microbiome and the compositional shifts in this microbiome in HPV-positive OPSCC. We also review potential mechanisms of crosstalk between HPV and specific microorganisms. Additional research is needed to understand these interactions and their roles on cancer development and progression.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11357953 | PMC |
| http://dx.doi.org/10.3389/fonc.2024.1425545 | DOI Listing |
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