AI Article Synopsis
- This study explores the link between C-reactive protein (CRP) and total bone trabecular score (TBS), highlighting a gap in existing research.
- Data from the NHANES database, involving 500 males and 633 females, was analyzed using linear regression to assess this relationship.
- Results showed a significant negative correlation between CRP and TBS, suggesting that higher inflammation levels could negatively impact bone health, which could inform future osteoporosis treatment and prevention strategies.
Article Abstract
Objectives: The association between C-reactive protein and bone density has been primarily investigated in previous studies, with little to no research investigating its relationship with total bone trabecular score.
Methods: Data from the NHANES database (500 males and 633 females) were utilized in this study to perform a multiple weighted linear regression analysis to estimate this relationship of CRP and TBS. Subsequently, population characterization, univariate logistic regression analysis, subgroup and interaction analysis were in progress.
Results: Upon covariate adjustment, the analysis revealed a notable negative correlation between CRP and TBS(β=-0.0081,95% CI (-0.0142, -0.0019), P = 0.009). Furthermore, no interactions were detected within any subgroups.
Conclusion: This finding enhances our comprehension of the relationship in inflammation and bone health, offering the novel research outlook for the treatment and prevention of osteoporosis and osteoporotic fractures.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11360293 | PMC |
| http://dx.doi.org/10.1186/s13018-024-05014-1 | DOI Listing |
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