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Plasma DNA Methylation-Based Biomarkers for MPNST Detection in Patients With Neurofibromatosis Type 1.
Mol Carcinog
January 2025
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Article Synopsis
- Malignant peripheral nerve sheath tumors (MPNSTs) show altered DNA methylation patterns, suggesting these changes could be used as specific biomarkers for NF1 patient screening.
- Researchers conducted a study involving DNA methylation profiling from tumor and adjacent tissue samples of 13 MPNST patients, finding 73 candidate CpGs that could distinguish MPNSTs from neurofibromas.
- Five validated biomarkers demonstrated high sensitivity and specificity in tissue detection, and higher methylation levels were observed in plasma tests, indicating potential for early detection of MPNST in NF1 patients.
Spatial Lipidomics Reveals Myelin Defects and Protumor Macrophage Infiltration in Malignant Peripheral Nerve Sheath Tumor Adjacent Nerves.
Lab Invest
January 2025
Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:
Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas arising from peripheral nerves, accounting for 3% to 5% of soft tissue sarcomas. MPNSTs often recur locally, leading to poor survival. Achieving tumor-free surgical margins is essential to prevent recurrence, but current methods for determining tumor margins are limited, highlighting the need for improved biomarkers.
View Article and Find Full Text PDFProfiling the cancer-prone microenvironment in a zebrafish model for MPNST.
Oncogene
February 2025
Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Article Synopsis
- Microenvironmental factors play a key yet unclear role in the progression of soft tissue sarcomas, especially during their onset.
- A novel zebrafish model was developed to differentiate among microenvironmental, precancerous, and cancer cells, focusing on malignant peripheral nerve sheath tumors (MPNST), which grow aggressively.
- The study reveals that specific inflammatory signaling pathways are activated during the transition from precancerous to cancerous states, highlighting the role of macrophages and identifying periostin as a significant protein in MPNST progression.
Malignant Peripheral Nerve Sheath Tumor (MPNST) With Smooth Muscle Differentiation of the Uterus-A Case Report With Emphasis on Diagnostic Pitfalls and Value of DNA Methylation Analysis.
Genes Chromosomes Cancer
November 2024
Department of Pathology, School of Clinical Medicine, The University of Hong Kong, Hong Kong, China.
With no more than two dozen cases reported in the literature, malignant peripheral nerve sheath tumor (MPNST) is a rare primary mesenchymal neoplasm arising in the female genital tract. Most cases occurred in middle-aged adults with high grade histology, unfavorable clinical outcome, and no history of neurofibromatosis type 1. Its extreme rarity in this site no doubt poses a diagnostic challenge during routine clinical practice.
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