AI Article Synopsis
- - Medical dressings with enhanced regenerative capabilities and biocompatibility are crucial in clinical settings, leading to the development of a new hybrid wound dressing (PCL/SerMA/DMOG).
- - This dressing combines electrospun PCL membranes with a hydrogel that releases DMOG in a sustained manner, promoting the growth and movement of human endothelial cells and aiding in vascularization.
- - In use, the PCL/SerMA/DMOG dressing significantly speeds up wound healing by enhancing blood vessel formation, collagen production, and overall tissue regeneration.
Article Abstract
Medical dressings with multifunctional properties, including potent regeneration capability and good biocompatibility, are increasingly needed in clinical practice. In this study, we reported a novel hybrid wound dressing (PCL/SerMA/DMOG) that combines electrospun PCL membranes with DMOG-loaded methacrylated sericin (SerMA) hydrogel. In such a design, DMOG molecules are released from the hybrid dressing in a sustained manner. A series ofassays demonstrated that DMOG-loaded hybrid dressing has multiple biological functions, including promotion of human umbilical vein endothelial cells proliferation and migration,vascularization, and the generation of intracellular NO. When applied to the cutaneous wound, the PCL/SerMA/DMOG dressing significantly accelerated wound closure and tissue regeneration by promoting angiogenesis in the wound area, collagen deposition, and cell proliferation within the wound bed. These results highlight the potential clinical application of PCL/SerMA/DMOG hybrid dressings as promising alternatives for accelerating wound healing via improved biocompatibility and angiogenesis amelioration.
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| http://dx.doi.org/10.1088/1748-605X/ad7563 | DOI Listing |
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