A novel electrochemical sensor for rapid detection of sulfathiazole by integrating [(4,4'-bipy/PMoCo)] modified electrode.

In this study, we focused on the successful construction of [(4,4'-bipy/PMoCo)] modified electrodes using the layer-by-layer assembly method for the sensitive detection of sulfathiazole (ST). The redox reaction between ST and the metal ions in the modified layer leads to the transfer of electrons, resulting in the generation of the electrical signal. The introduction of 4,4'-bipyridine (4,4'-bipy) enhanced the molecular recognition of ST by the modified electrode. Under the combined effect of PMoCo and 4,4'-bipy, the sensor exhibited good performance for ST detection (LOD: 0.5616 μM, linear ST concentration range: 0-50 μM). The spiked recoveries of the two groups were 84.4%-103.2% and 90.9%-109.4% for the determination of ST residues in large yellow croaker and South American white shrimp, respectively. In addition, the electrode showed excellent performance in terms of stability, reproducibility, and anti-interference ability.