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A unified flow strategy for the preparation and use of trifluoromethyl-heteroatom anions. | LitMetric

AI Article Synopsis

  • * The researchers introduced a modular flow platform that simplifies the synthesis of heteroatom-CF compounds using common organic precursors and cesium fluoride as the fluorine source.
  • * This new approach allows for quick and eco-friendly production of trifluoromethyl-containing molecules, making it suitable for larger scale manufacturing thanks to flow technology.

Article Abstract

The trifluoromethyl group (CF) is a key functionality in pharmaceutical and agrochemical development, greatly enhancing the efficacy and properties of resulting compounds. However, attaching the CF group to heteroatoms such as sulfur, oxygen, and nitrogen poses challenges because of the lack of general synthetic methods and reliance on bespoke reagents. Here, we present a modular flow platform that streamlines the synthesis of heteroatom-CF motifs. Our method uses readily available organic precursors in combination with cesium fluoride as the primary fluorine source, facilitating the rapid generation of -trifluoromethyl(R) [NCF(R)], SCF (trifluoromethylthio), and OCF (trifluoromethoxy) anions on demand without reliance on perfluoroalkyl precursor reagents. This strategy offers a more environmentally friendly synthesis of trifluoromethyl(heteroatom)-containing molecules, with the potential for scalability in manufacturing processes facilitated by flow technology.

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Source
http://dx.doi.org/10.1126/science.adq2954DOI Listing

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