Speckle degrades the quality of optical coherence tomography (OCT) images and impedes their visual interpretation. Current hardware methods for speckle suppression necessitate difficult hardware modifications. As a result, algorithmic approaches for speckle suppression generally lack validation or training with physically meaningful ground truth. Here, we demonstrate angular compounding through tilting of the sample with a motorized rotation stage. Tomograms acquired at different tilt angles are related to each other through a physics-informed affine map, which can be retrieved directly from the measurement data. Using a mechanical sample tilting stage obviates the need to alter the OCT hardware and enables effective angular compounding with existing OCT instruments.
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http://dx.doi.org/10.1364/OL.533271 | DOI Listing |
Biomimetics (Basel)
December 2024
School of Optics and Photonics, Beijing Institute of Technology, Beijing 100081, China.
This study presents a cutting-edge imaging technique for special unmanned vehicles (UAVs) designed to enhance tunnel inspection capabilities. This technique integrates ghost imaging inspired by the human visual system with lateral inhibition and variable resolution to improve environmental perception in challenging conditions, such as poor lighting and dust. By emulating the high-resolution foveal vision of the human eye, this method significantly enhances the efficiency and quality of image reconstruction for fine targets within the region of interest (ROI).
View Article and Find Full Text PDFHerpesviruses, including the oncogenic Epstein-Barr Virus (EBV), must bypass host DNA sensing mechanisms to establish infection. The first viral latency protein expressed, EBNA-LP, is essential for transformation of naïve B cells, yet its role in evading host defenses remains unclear. Using single-cell RNA sequencing of EBNA-LP-Knockout (LPKO)-infected B cells, we reveal an antiviral response landscape implicating the 'speckled proteins' as key restriction factors countered by EBNA-LP.
View Article and Find Full Text PDFActa Pharmacol Sin
December 2024
University of Science and Technology of China, Hefei, 230026, China.
Abnormal activation of NLRP3 inflammasome causes the progression of gout, and no small-molecule inhibitor of NLRP3 has been approved yet for clinical use. In this study we established a nigericin-induced inflammasome activation cell model for screening of a natural product library by measuring IL-1β secretion in cell supernatants. Among 432 compounds tested, we found that hypocrellin A (HA), one of the major active components of a traditional ethnic medicinal fungus Hypocrella bambusea in the Northwest Yunnan of China, exhibited the highest inhibition on IL-1β production (IC = 0.
View Article and Find Full Text PDFEgypt Heart J
December 2024
Cardiology Division of Internal Medicine Department, Faculty of Medicine, South Valley University, Qena, 83523, Egypt.
Background: Previous studies on the relation of sST2 with atherosclerotic disease mostly focused on the predictive value of sST2 for heart failure. However, there is no definite conclusion about the correlation between sST2 level and a complex coronary lesion morphology detected with coronary angiography (CAG). The purpose of this work was to know sST2 level and 3D speckle-tracking echocardiography as predictor of coronary artery disease (CAD) severity in chronic coronary syndrome (CCS) individuals using Gensini score.
View Article and Find Full Text PDFPhys Rev Lett
November 2024
MESA+ Institute for Nanotechnology, University of Twente, The Netherlands.
We investigate the effect of a mirror-symmetry plane in multiple-scattering media under plane-wave illumination along the symmetry plane. Designed and fabricated samples' optical transport properties are compared quantitatively with three-dimensional modeling. Strong polarization-dependent deviations of the bulk speckle-averaged intensity distribution at the symmetry plane are observed, showing either up to a factor 2 enhancement or complete suppression of the ensemble-averaged intensities.
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