The sandwich generation faces dual responsibilities of supporting parents and raising children, resulting in heightened levels of stress and negative work-related outcomes. Despite a wealth of research on the sandwich generation, few studies have examined the specific nature of the multigenerational needs of the sandwich generation. Accordingly, we introduce a new concept termed family intergenerational stress (FIS), which refers to the interaction and integration of stresses from elder caregiving, child-rearing, and associated challenges with self-definition. Through the lens of FIS, we collected interview data from 137 sandwich generation employees, secondary network data, and field observation data from 21 employees. We further used grounded theory to explore employees' stress and coping responses to dual family responsibilities. Findings indicate that employees with both elder caregiving and child-rearing responsibilities experience FIS. This, in turn, threatens their identity as an ideal worker and is associated with lower work engagement. Findings further reveal that in coping with FIS, employees adopt different identity-based strategies. Theoretical and practical implications are discussed. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
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http://dx.doi.org/10.1037/ocp0000388 | DOI Listing |
Front Immunol
January 2025
Department of Otorhinolaryngology, Head and Neck surgery, University Hospital Leipzig, Leipzig, Germany.
Background: Adding pembrolizumab, an anti-PD-1 antibody approved for treatment of head and neck squamous cell carcinoma (HNSCC) to neoadjuvant (induction-) chemotherapy utilizing docetaxel and cisplatin (TP) followed by radiotherapy may improve outcome in larynx organ-preservation (LOP) that is investigated in the European Larynx-Organ preservation Study (ELOS). As biomarkers for response to TP and pembrolizumab +TP are missing but may include cytokines, this work aims on determining cytokines potentially linked to outcome as prognostic markers sufficient to predict and/or monitor response to successful LOP.
Methods: Collagenase IV digests were generated from 47 histopathological confirmed HNSCC tumor samples and seeded in 96-well plates containing pembrolizumab, docetaxel, cisplatin either solely or in binary or ternary combination.
Front Microbiol
January 2025
College Food Science and Light Industry, Nanjing Tech University, Nanjing, China.
A colloidal gold immunochromatographic assay (ICA) based on a dual-antibody sandwich method was developed for the rapid and convenient detection of () antigens in the early stages of infection. Monoclonal antibodies designed as 5B3 targeting the conserved region of 56 kDa outer membrane protein in various strains of were generated through cell fusion and screening techniques and combined with previously prepared polyclonal antibodies as detection antibodies to establish the ICA. Colloidal gold and polyclonal antibody-colloidal gold complexes were synthesized under optimized conditions.
View Article and Find Full Text PDFAnal Chem
January 2025
State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, College of Energy, Discipline of Intelligent Instrument and Equipment, Cancer Center and Department of Breast and Thyroid Surgery, Department of Ultrasound, Xiang'an Hospital of Xiamen University, School of Medicine, Laboratory Animal Center Xiamen University, Xiamen University, Xiamen 361005, China.
With the increasing incidence of thyroid cancer worldwide and the increasing demand for surgery, the risk of parathyroid injury is also increasing, which will lead to postoperative hypoparathyroidism (HP) and hypocalcemia. In order to improve the quality of life of patients after surgery, there is an urgent need to develop a novel platform that can identify the parathyroid gland immediately during surgery. The parathyroid gland promotes the increase of blood calcium concentration by secreting parathyroid hormone (PTH).
View Article and Find Full Text PDFACS Nano
January 2025
Creative Research Initiative Center for Nanospace-confined Chemical Reactions (NCCR), Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea.
Unlike homogeneous metal complexes, achieving absolute control over reaction selectivity in heterogeneous catalysts remains a formidable challenge due to the unguided molecular adsorption/desorption on metal-surface sites. Conventional organic surface modifiers or ligands and rigid inorganic and metal-organic porous shells are not fully effective. Here, we introduce the concept of "ligand-porous shell cooperativity" to desirably reaction selectivity in heterogeneous catalysis.
View Article and Find Full Text PDFAoB Plants
January 2025
Department of Biodiversity and Biostatistics, Institute of Biosciences of Botucatu, São Paulo State University (UNESP), Professor Antônio Celso Wagner Zagnin street, 250, District of Rubião Júnior, 18618-970, Botucatu City, São Paulo State, Brazil.
The anatomical and cytological characteristics of the mucilage-secretory system have been widely studied in Malvaceae. However, conflicting information regarding the morphological nature of secretory structures exists, and some remain poorly understood. In this sense, some secretory structures in Malvaceae are not characterized as typical isolated idioblasts, canals, or cavities.
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