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How I Treat AML relapse after allogeneic HCT.
Blood
December 2024
Dana-Farber Cancer Institute, BOSTON, Massachusetts, United States.
Allogeneic hematopoietic stem-cell transplantation (HCT) is one of the principal curative approaches in the treatment of acute myeloid leukemia (AML); however, relapse post-transplantation remains a catastrophic event with poor prognosis. The incidence of relapse has remained unchanged over the last three decades despite an evolving understanding of the immunobiology of the graft-versus leukemia effect and the immune escape mechanisms that lead to post-HCT relapse. The approach to post-transplant relapse is highly individualized and is dictated both by disease biology and genomics as well as the patient's clinical status at the time of relapse and the interval between relapse and transplantation.
View Article and Find Full Text PDFPhase Separation of CuPd Alloy Nanocatalysts in CO Oxidation.
ACS Nano
December 2024
Institute of Molecular Plus, Tianjin University, Tianjin 300072, China.
Alloy nanocatalysts exhibit enhanced activity, selectivity, and stability mainly due to their versatile phases and atomic structures. However, nanocatalysts' "real" functional structures may vary from their as-synthesized status due to the structural and chemical changes during the activation and reaction conditions. Herein, we studied the activated CuPd/CeO nanocatalysts under the CO oxidation reaction featuring an atomic-scale phase separation process, resulting in a notable "hysteresis" in catalyst performance.
View Article and Find Full Text PDFZYG-12/Hook's dual role as a dynein adaptor for early endosomes and nuclei is regulated by alternative splicing of its cargo binding domain.
Mol Biol Cell
December 2024
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.
The microtubule motor cytoplasmic dynein-1 transports and positions various organelles, but the molecular basis of this functional diversity is not fully understood. Cargo adaptors of the Hook protein family recruit dynein to early endosomes (EE) in fungi and human cells by forming the FTS-Hook-FHIP (FHF) complex. By contrast, the Hook homolog ZYG-12 recruits dynein to the nuclear envelope (NE) in the meiotic gonad and mitotic early embryo by forming a Linker of Nucleoskeleton and Cytoskeleton (LINC) complex.
View Article and Find Full Text PDFRelationship with Adults in Organized Sports and Non-Sports Activities and Links with Psychological Adjustment in Adolescence: A 6-Year Longitudinal Study.
J Youth Adolesc
December 2024
Faculty of Education, Université Laval, Québec, QC, Canada.
Relationships with adults in organized activities play a crucial role in the positive outcomes associated with these experiences, yet little is known about how these relationships evolve throughout adolescence or how they are differentially associated with mental health. Important distinctions could also be made regarding activity types. The sample consisted of 292 participants (58% female; M age = 12.
View Article and Find Full Text PDFSearching and Using MobiDB Resource 6 to Explore Predictions and Annotations for Intrinsically Disordered Proteins.
Curr Protoc
December 2024
Department of Biomedical Sciences, University of Padova, Padova, Italy.
Intrinsically disordered proteins (IDPs) make up around 30% of eukaryotic proteomes and play a crucial role in cellular processes and in pathological conditions such as neurodegenerative disorders and cancers. However, IDPs exhibit dynamic conformational ensembles and are often involved in the formation of biomolecular condensates. Understanding the function of IDPs is critical to research in many areas of science.
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