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Filename: controllers/Detail.php
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Filename: controllers/Detail.php
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File: /var/www/html/application/controllers/Detail.php
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Function: _error_handler
File: /var/www/html/index.php
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Message: Trying to access array offset on value of type null
Filename: controllers/Detail.php
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The placenta is a gatekeeper between the mother and fetus, adapting its structure and functions to support optimal fetal growth. Studies exploring adaptations of placentae that support the development of genetically small fetuses are lacking. Here, using a mouse model of impaired fetal growth, achieved by deleting insulin-like growth factor 2 (Igf2) in the epiblast, we assessed placental nutrient transfer and umbilical artery (UA) blood flow during late gestation. At embryonic day (E) 15.5, we observed a decline in the trans-placental flux of glucose and system A amino acids (by using 3H-MeG and 14C-MeAIB), proportionate to the diminished fetal size, whereas UA blood flow was normal. However, at E18.5, the trans-placental flux of both tracers was disproportionately decreased and accompanied by blunted UA blood flow. Feto-placental growth and nutrient transfer were more impaired in female conceptuses. Thus, reducing the fetal genetic demand for growth impairs the adaptations in placental blood flow and nutrient transport that normally support the fast fetal growth during late gestation. These findings have important implications for our understanding of the pathophysiology of pregnancies afflicted by fetal growth restriction.
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http://dx.doi.org/10.1242/dmm.050719 | DOI Listing |
Pediatr Surg Int
December 2024
Department of Pediatric Surgery, Karamanoğlu Mehmetbey University, Karaman, Türkiye.
Background: We aimed to evaluate the epidemiological characteristics, risk factors and prognostic factors affecting the clinical follow-up of patients who underwent tube thoracostomy due to pneumothorax in the neonatal intensive care unit of our hospital.
Methods: In our study; 54 cases with neonatal pneumothorax underwent tube thoracostomy followed up in the neonatal intensive care unit between April 2014 and March 2023 were retrospectively analyzed.
Results: The gestational age of the cases was between 28 and 38 weeks; 24 (44.
J Fish Dis
December 2024
Key Laboratory of Fishery Drug Development, Ministry of Agriculture and Rural Affairs, Guangdong Provincial Key Laboratory of Aquatic Animal Immunology and Sustainable Aquaculture, Pearl River Fishery Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, China.
Largemouth bass (Micropterus salmoides), a freshwater fish species, is cultivated widely across China. The industry has been greatly affected by various viral diseases. We generated a new immortal cell line from the fin of M.
View Article and Find Full Text PDFEpilepsia
December 2024
Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Objective: This study was undertaken to characterize the clinical and genetic features of patients with 22q11.2 deletion syndrome (22q11.2DS) and generalized epilepsy compared with 22q11.
View Article and Find Full Text PDFAlcohol Clin Exp Res (Hoboken)
December 2024
Mt. Hope Family Center, University of Rochester, Rochester, New York, USA.
Fetal alcohol spectrum disorders (FASD) are among the most common neurodevelopmental disabilities. Individuals with FASD experience postnatal adversity (PA; i.e.
View Article and Find Full Text PDFJ Biomed Mater Res A
January 2025
BYU Applied Biomedical Engineering Laboratory, Brigham Young University, Provo, Utah, USA.
Wearable nanocomposite stretch sensors are an exciting new development in biomaterials for biomechanical motion-tracking technology, with applications in the treatment of low back pain, knee rehabilitation, fetal movement tracking, and other fields. When strained, the resistance of the low-cost sensors is reduced, enabling human motion to be monitored using a suitable sensor array. However, current sensor technologies have exhibited significant drift, in the form of increased electrical resistance, if left stored in typical room conditions.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!