AI Article Synopsis
- The study explores how dietary advanced glycation end-products (dAGEs) affect host health and gut microbiota, identifying bound AGEs as the main entry point into the body, especially through diet.
- It reveals that high AGE diets lead to significant early changes in gut microbiota, particularly an increase in certain bacteria like Bacteroides and Parabacteroides, which may help utilize dAGEs.
- Additionally, the research indicates that these dietary changes influence metabolic processes, especially in lipid and carbohydrate pathways, ultimately impacting the host's metabolic balance over both short and long terms.
Article Abstract
This study delves into the dynamics of dietary advanced glycation end-products (dAGEs) on host health and gut microbiota. Using C-labeled carboxymethyllysine (CML) bound casein, we identify bound AGEs as the primary entry route, in contrast to free AGEs dominating urinary excretion. Specifically, our results show that the kidneys accumulate 1.5 times more dAGEs than the liver. A high AGE (HA) diet prompts rapid gut microbiota changes, with an initial stress-induced mutation phase, evidenced by a 20% increase in Bacteroides and Parabacteroides within the first week, followed by stabilization. These bacteria emerge as potential dAGE-utilizing bacteria, influencing the microbiota composition. Concurrent metabolic shifts affect lipid and carbohydrate pathways, with lipid metabolism alterations persisting over time, impacting host metabolic homeostasis. This study illuminates the intricate interplay between dietary AGEs, gut microbiota, and host health, offering insights into the health consequences of short- and long-term HA dietary patterns.
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| http://dx.doi.org/10.1039/d4fo01545b | DOI Listing |
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