AI Article Synopsis
- * A key challenge in utilizing RNA therapies is effectively delivering them to the central nervous system through the blood-brain barrier (BBB).
- * This review emphasizes therapeutic RNA, particularly small interfering RNAs (siRNAs), and explores various strategies for treating neurodegenerative diseases to facilitate their clinical application.
Article Abstract
Neurodegenerative diseases are devastating diseases that severely affect the health of people all over the world. RNA therapies have become one of the most promising critical drug treatments for neurodegenerative diseases due to their excellent gene and protein editing effects. However, the successful transport of RNA the systemic route to the central nervous system remains one of the major obstacles in treating neurodegenerative diseases. This review will focus on therapeutic RNA that can successfully overcome the blood-brain barrier (BBB), with particular attention to small interfering RNAs (siRNAs), focusing on different types of neurodegenerative disease treatment strategies and accelerating their translation into clinical practice.
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| http://dx.doi.org/10.1039/d4bm00878b | DOI Listing |
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