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Adaptive immunity of materials: Implications for tissue healing and regeneration. | LitMetric

Adaptive immunity of materials: Implications for tissue healing and regeneration.

Bioact Mater

Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, Republic of Korea.

Published: November 2024

AI Article Synopsis

  • Recent findings highlight the importance of adaptive immunity in materials for enhancing tissue healing and regenerative outcomes.
  • Materials can influence immune responses, particularly involving T and B cells and their interactions with innate immune cells, which play a crucial role in the healing process.
  • The study examines how different physicochemical properties of materials, such as shape and rigidity, affect adaptive immune responses and shows how biomaterials can impact healing, cancer progression, and fibrosis.

Article Abstract

Recent cumulative findings signify the adaptive immunity of materials as a key agenda in tissue healing that can improve regenerative events and outcomes. Modulating immune responses, mainly the recruitment and functions of T and B cells and their further interplay with innate immune cells (e.g., dendritic cells, macrophages) can be orchestrated by materials. For instance, decellularized matrices have been shown to promote muscle healing by inducing T helper 2 (Th2) cell immunity, while synthetic biopolymers exhibit differential effects on B cell responses and fibrosis compared decellularized matrices. We discuss the recent findings on how implantable materials instruct the adaptive immune events and the subsequent tissue healing process. In particular, we dissect the materials' physicochemical properties (shape, size, topology, degradation, rigidity, and matrix dynamic mechanics) to demonstrate the relations of these parameters with the adaptive immune responses and the underlying biological mechanisms. Furthermore, we present evidence of recent phenomena, including tissue healing, cancer progression, and fibrosis, wherein biomaterials potentially shape adaptive immune cell functions and outcomes. Our discussion will help understand the materials-regulated immunology events more deeply, and offer the design rationale of materials with tunable matrix properties for accelerated tissue repair and regeneration.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11350271PMC
http://dx.doi.org/10.1016/j.bioactmat.2024.07.027DOI Listing

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