AI Article Synopsis
- Scientists are studying plant peptides from 27 Thai plants to see if they can fight against superbugs that resist antibiotics.
- They found that some peptides from two specific plants were really good at stopping bacterial growth and could stay effective even in cold temperatures for a long time.
- The research suggests that these plant peptides could be a helpful tool in the fight against antibiotic resistance and encourages more studies to understand how they work.
Article Abstract
Context: Plant peptides garner attention for their potential antimicrobial properties amid the rising concern over antibiotic-resistant bacteria.
Objective: This study investigates the antibacterial potential of crude peptide extracts from 27 Thai plants collected locally.
Materials And Methods: Peptide extracts from 34 plant parts, derived from 27 Thai plants, were tested for their antimicrobial efficacy against four highly resistant bacterial strains: MRSA, , , and . The stability of these peptide extracts was examined at different temperatures, and the synergistic effects of two selected plant peptide extracts were investigated. Additionally, the time-kill kinetics of the individual extracts and their combination were determined against the tested pathogens.
Results: Peptides from L. and O. Fedtsch (Amaryllidaceae) were particularly potent, inhibiting bacterial growth with MICs ranging from 1.43 to 86.50 µg/mL. The consistent MICs and MBCs of these extracts across various extraction time points highlight their reliability. Stability tests reveal that these peptides maintain their antimicrobial activity at -20 °C for over a month, emphasizing their durability for future exploration and potential applications in addressing antibiotic resistance. Time-kill assays elucidate the time and concentration-dependent nature of these antimicrobial effects, underscoring their potent initial activity and sustained efficacy over time.
Discussion And Conclusions: This study highlights the antimicrobial potential of -derived peptides, endorsing them for combating antibiotic resistance and prompting further investigation into their mechanisms.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11363733 | PMC |
| http://dx.doi.org/10.1080/13880209.2024.2395517 | DOI Listing |
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