AI Article Synopsis
- - Filoviruses like Marburg and Ebola cause severe outbreaks with high death rates, and while there’s an FDA-approved Ebola vaccine, it doesn’t protect against Marburg.
- - A new vaccine, rVSV-MARV, was tested on cynomolgus macaques and showed effective immunization with a single dose, leading to survival against lethal Marburg exposure.
- - The vaccinated monkeys did not exhibit significant illness or disease symptoms, suggesting that rVSV-MARV is both safe and effective for preventing Marburg hemorrhagic fever.
Article Abstract
Filoviruses, like the Marburg (MARV) and Ebola (EBOV) viruses, have caused outbreaks associated with significant hemorrhagic morbidity and high fatality rates. Vaccines offer one of the best countermeasures for fatal infection, but to date only the EBOV vaccine has received FDA licensure. Given the limited cross protection between the EBOV vaccine and Marburg hemorrhagic fever (MHF), we analyzed the protective efficacy of a similar vaccine, rVSV-MARV, in the lethal cynomolgus macaque model. NHPs vaccinated with a single dose (as little as 1.6 × 10 pfu) of rVSV-MARV seroconverted to MARV G-protein prior to challenge on day 42. Vaccinemia was measured in all vaccinated primates, self-resolved by day 14 post vaccination. Importantly, all vaccinated NHPs survived lethal MARV challenge, and showed no significant alterations in key markers of morbid disease, including clinical signs, and certain hematological and clinical chemistry parameters. Further, apart from one primate (from which tissues were not collected and no causal link was established), no pathology associated with Marburg disease was observed in vaccinated animals. Taken together, rVSV-MARV is a safe and efficacious vaccine against MHF in cynomolgus macaques.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11359148 | PMC |
| http://dx.doi.org/10.3390/v16081181 | DOI Listing |
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