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Clinically Relevant Characterization and Comparison of Ryaltris and Other Anti-Allergic Nasal Sprays. | LitMetric

AI Article Synopsis

  • The study focuses on the importance of how nasal suspensions containing corticosteroids behave in the body, especially their efficacy after being administered.
  • It compares Ryaltris, a nasal spray containing mometasone furoate and olopatadine, with other products like Dymista, Nasonex, and Avamys using both traditional and innovative characterization methods.
  • Results showed that Ryaltris has higher viscosity and a faster dissolution rate, suggesting it may offer better clinical benefits compared to the other nasal products.

Article Abstract

The deposition, residence time, and dissolution profile of nasal suspensions containing corticosteroids play a key role in their in vivo efficacy after administration. However, the conventional methods available to characterize nasal products appear to be unsuitable to exhaustively cover these aspects. The work aims to investigate technological aspects of Ryaltris (mometasone furoate and olopatadine hydrochloride nasal spray) compared to other commercial anti-allergic nasal products, namely, Dymista (azelastine hydrochloride and fluticasone propionate), Nasonex (mometasone furoate), and Avamys (fluticasone furoate). Innovative characterization methods were combined with more traditional approaches to investigate the anti-allergic nasal sprays. These methods applied together allowed to differentiate between the different products and provided a clear picture of the nasal product behavior in terms of drug dissolution and deposition. In particular, the dissolution tests were performed exploiting the Respicell apparatus, an innovative technique that allows for the investigation of inhalation products. Then, formulation viscosities were considered along with a formulation flow test on an inclined plane. Finally, the intranasal deposition profile of the commercial formulations was determined using a silicon nasal cast. The results highlight in vitro significant differences in terms of viscosity as well as dissolution rate of the nasal products, with Ryaltris showing a higher viscosity and lower flow compared to other products, which, along with a corticosteroid faster dissolution rate than Dymista, suggest a potential advantage in terms of clinical behavior.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11357686PMC
http://dx.doi.org/10.3390/pharmaceutics16080989DOI Listing

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