AI Article Synopsis
- African swine fever virus (ASFV) is a deadly virus affecting pigs, with mortality rates as high as 100%, first identified in Kenya in 1921 and spreading globally, including a serious outbreak in China in 2018.
- The immune system's T and B cells recognize specific patterns, called antigenic epitopes, which are essential for fighting ASFV and understanding these can help develop new treatments and vaccines.
- This review discusses advancements in identifying these antigenic epitopes and the role of vaccine adjuvants, which enhance the immune response, in the effort to create effective vaccines against ASFV.
Article Abstract
African swine fever virus (ASFV), a highly virulent double-stranded DNA virus, poses a significant threat to global pig farming, with mortality rates in domestic pigs reaching up to 100%. Originating in Kenya in 1921, ASFV has since proliferated to Western Europe, Latin America, Eastern Europe, and most recently China in 2018, resulting in substantial global agricultural losses. Antigenic epitopes, recognized by the immune system's T cells and B cells, are pivotal in antiviral immune responses. The identification and characterization of these antigenic epitopes can offer invaluable insights into the immune response against ASFV and aid in the development of innovative immunotherapeutic strategies. Vaccine adjuvants, substances that amplify the body's specific immune response to antigens, also play a crucial role. This review provides an overview of the progress in studying T/B-cell epitopes in ASFV proteins and ASFV vaccine adjuvants, highlighting their role in the immune response and potential use in new vaccine development.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11357537 | PMC |
| http://dx.doi.org/10.3390/pathogens13080706 | DOI Listing |
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