AI Article Synopsis
- - STIs caused by bacterial pathogens pose serious challenges to public health, impacting reproductive health and increasing risks of complications like pelvic inflammatory disease and infertility.
- - Preventative measures are complicated due to the asymptomatic nature of these infections, the necessity for continuous screening, and rising antibiotic resistance, particularly for gonorrhea and limited penicillin availability for syphilis.
- - Although vaccines are available for some viral STIs, there are no current vaccines for bacterial STIs, prompting research into the immune responses in the female genital tract to help in vaccine development.
Article Abstract
Sexually transmitted infections (STIs) caused by bacterial pathogens , , and present significant public health challenges. These infections profoundly impact reproductive health, leading to pelvic inflammatory disease, infertility, and increased susceptibility to other infections. Prevention measures, including antibiotic treatments, are limited by the often-asymptomatic nature of these infections, the need for repetitive and continual screening of sexually active persons, antibiotic resistance for gonorrhea, and shortages of penicillin for syphilis. While vaccines exist for viral STIs like human papillomavirus (HPV) and hepatitis B virus (HBV), there are no vaccines available for bacterial STIs. This review examines the immune responses in the female genital tract to these bacterial pathogens and the implications for developing effective vaccines against bacterial STIs.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11359697 | PMC |
| http://dx.doi.org/10.3390/vaccines12080863 | DOI Listing |
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