AI Article Synopsis
- - The study focused on the levels of cytokines in aqueous humor from patients with idiopathic epiretinal membrane (iERM) to understand their relationship with disease severity.
- - Researchers analyzed samples from 16 iERM patients and 14 healthy controls, finding 19 cytokines significantly elevated in the iERM group, linked to inflammation and disease progression.
- - Findings suggest a connection between increased cytokine levels and the severity of iERM, highlighting the role of neuroinflammation in the disease's development.
Article Abstract
Background: To analyze the concentration of aqueous humor (AH) cytokines in eyes with idiopathic epiretinal membrane (iERM) and to investigate their potential correlation with disease severity.
Methods: Retrospective cross-sectional case-control institutional study. A total of 16 eyes of 16 iERM patients and 14 eyes of 14 age-matched healthy controls were enrolled. AH samples were analyzed for various biomarkers using a glass-chip protein array. Cytokines associated with inflammation, fibrosis, angiogenesis, and glial signal transduction were quantified.
Results: Significant differences in cytokine concentration were observed between the iERM group and controls, with 19 cytokines elevated in the iERM group (among them IL-6, IL-8, PDGF-AB, PDGF-BB, TGFB-1, TGFB-2, TGFB-3, VEGF A, VEGF C, VEGF D, < 0,05, 95% confidence interval). Correlation analysis revealed associations between cytokine levels and iERM severity. Notably, stages 2, 3, and 4 of iERM demonstrated increased levels of various biomarkers.
Conclusions: This study provides insights into the complex molecular interactions underlying iERM pathogenesis, describing a correlation between neuroinflammation and iERM severity.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11354064 | PMC |
| http://dx.doi.org/10.3390/diagnostics14161797 | DOI Listing |
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