AI Article Synopsis
- Crohn's disease (CD) is an inflammatory bowel disease that can affect the gastrointestinal tract and cause complications outside of it, and some patients have shown adverse effects after receiving the Pfizer-BioNTech mRNA vaccine.
- Following vaccination, some CD patients have experienced a reduced effectiveness of the biological drug Adalimumab and a worsening of their condition, correlated with changes in intestinal permeability and protein expression.
- The study aims to explore the effects of the SARS-CoV-2 Spike protein, particularly through extracellular vesicles, on the onset of Crohn's disease exacerbations and the potential impact on existing treatments.
Article Abstract
Crohn's disease (CD) is a type of inflammatory bowel disease (IBD) affecting the gastrointestinal tract that can also cause extra-intestinal complications. Following exposure to the mRNA vaccine BNT162b2 (Pfizer-BioNTech) encoding the SARS-CoV-2 Spike (S) protein, some patients experienced a lack of response to the biological drug Adalimumab and a recrudescence of the disease. In CD patients in progression, resistant to considered biological therapy, an abnormal increase in intestinal permeability was observed, more often with a modulated expression of different proteins such as Aquaporin 8 (AQP8) and in tight junctions (e.g., ZO-1, Claudin1, Claudin2, Occludin), especially during disease flares. The aim of this study is to investigate how the SARS-CoV-2 vaccine could interfere with IBD therapy and contribute to disease exacerbation. We investigated the role of the SARS-CoV-2 Spike protein, transported by extracellular vesicles (EVs), and the impact of various EVs components, namely, exosomes (EXOs) and microvesicles (MVs), in modulating the expression of molecules involved in the exacerbation of CD, which remains unknown.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11355036 | PMC |
| http://dx.doi.org/10.3390/ijms25168853 | DOI Listing |
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