AI Article Synopsis
- - Muscle disorders caused by tendon issues lead to reduced muscle function and atrophy, and Pulsed Electromagnetic Fields (PEMFs) may help improve tendon structure and muscle recovery.
- - A study on rats with induced Achilles tendinopathy showed that PEMF therapy resulted in significant metabolic changes, improving NAD signaling, ATP production, and enhancing the function of proteins related to muscle recovery.
- - The research demonstrated that PEMF treatment not only increased antioxidant protein levels but also restored important signaling proteins like PGC1alpha and YAP, and upregulated slow myosin isoforms, facilitating faster physiological recovery of muscle tissue.
Article Abstract
Tendon disorders often result in decreased muscle function and atrophy. Pulsed Electromagnetic Fields (PEMFs) have shown potential in improving tendon fiber structure and muscle recovery. However, the molecular effects of PEMF therapy on skeletal muscle, beyond conventional metrics like MRI or markers of muscle decline, remain largely unexplored. This study investigates the metabolic and structural changes in PEMF-treated muscle tissue using proteomics in a rat model of Achilles tendinopathy induced by collagenase. Sprague Dawley rats were unilaterally induced for tendinopathy with type I collagenase injection and exposed to PEMFs for 8 h/day. extracts from untreated or PEMF-treated rats were analyzed with LC-MS/MS, and proteomics differential analysis was conducted through label-free quantitation. PEMF-treated animals exhibited decreased glycolysis and increased LDHB expression, enhancing NAD signaling and ATP production, which boosted respiratory chain activity and fatty acid beta-oxidation. Antioxidant protein levels increased, controlling ROS production. PEMF therapy restored PGC1alpha and YAP levels, decreased by tendinopathy. Additionally, myosins regulating slow-twitch fibers and proteins involved in fiber alignment and force transmission increased, supporting muscle recovery and contractile function. Our findings show that PEMF treatment modulates NAD signaling and oxidative phosphorylation, aiding muscle recovery through the upregulation of YAP and PGC1alpha and increasing slow myosin isoforms, thus speeding up physiological recovery.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11354614 | PMC |
| http://dx.doi.org/10.3390/ijms25168852 | DOI Listing |
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