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Genetic Patterns of Oral Cavity Microbiome in Patients with Sickle Cell Disease. | LitMetric

AI Article Synopsis

  • - The study investigates the oral microbiota differences between healthy individuals and those with sickle cell anemia (SCA) in the Middle East, highlighting the need for more research on this genetic disorder.
  • - Saliva samples from 36 participants (18 with SCA and 18 healthy controls) were analyzed using next-generation sequencing to identify and quantify various bacterial species in their oral microbiomes.
  • - Findings reveal that alterations in the oral microbiota may increase health complications for SCA patients, suggesting that salivary diagnostics could be useful for predicting and preventing related diseases in the future.

Article Abstract

The Middle Eastern prevalence of sickle cell anemia, a genetic disorder that affects red blood cells, necessitates additional research. On a molecular level, we sought to identify and sort the oral microbiota of healthy individuals and those with sickle cell anemia. Furthermore, it is crucial to comprehend how changes in the genetic makeup of the oral microbiota impact the state of sickle cell anemia. Using next-generation sequencing, the 16S rRNA amplicon was examined using saliva samples from 36 individuals with sickle cell anemia and healthy individuals. These samples were obtained from sickle cell anemia patients (18 samples) and healthy control participants (controls, 18 samples). Various analyses are conducted using bioinformatic techniques to identify distinct species and their relative abundance. , followed by , , and were the most prevalent genera of bacteria in the saliva of the SCA and non-SCA individuals according to our findings. , , and species were the dominant species in both sickle cell anemia and non-sickle cell anemia subjects. , , , and spp. were the most prevalent bacterial spp. in the studied SCA cases. The sequencing of the 16S rRNA gene yielded relative abundance values that were visualized through a heatmap analysis. Alterations in the oral microflora's constitution can significantly affect the susceptibility of sickle cell anemia patients to develop more severe health complications. Salivary diagnosis is a potential tool for predicting and preventing oral microbiome-related diseases in the future.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11354819PMC
http://dx.doi.org/10.3390/ijms25168570DOI Listing

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