Non-bacterial thrombotic endocarditis (NBTE) is a form of non-infective endocarditis characterized by the deposition of sterile fibrin and platelets on cardiac valves. Even though some studies have identified important pathophysiological features, many aspects remain poorly understood. Given its wide availability, transthoracic echocardiography is typically the initial diagnostic approach to the patient. Additionally, recent technological advancements in transesophageal echocardiography, such as three-dimensional and multiplanar reconstruction analysis, have significantly improved diagnostic accuracy over time. By presenting our case series and performing a literature review, we focused on the main pathophysiologic, diagnostic, and therapeutic aspects of this rare but potentially life-threatening disease.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11355671 | PMC |
| http://dx.doi.org/10.3390/jcm13164904 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Acute Myocardial and Hemorrhagic Cerebral Infarction Secondary to Non-bacterial Thrombotic Endocarditis in a Patient with Advanced Uterine and Ovarian Cancer.
Intern Med
December 2024
Division of Cardiovascular Surgery, Oita Prefectural Hospital, Japan.
Non-bacterial thrombotic endocarditis (NBTE) causes myocardial and cerebral infarctions and is associated with advanced stages of malignancy. However, only a few cases of myocardial and cerebral infarctions have been reported in the same patient. We herein report a 47-year-old woman with advanced uterine and ovarian cancer who experienced acute myocardial infarction (MI) after receiving chemotherapeutic intervention for the cancer and hemorrhagic cerebral infarction 1 month after admission for acute MI, attributable to NBTE of the aortic valve.
View Article and Find Full Text PDFTopography of ischemic strokes in cancer-associated non-bacterial thrombotic endocarditis: A single-institution descriptive case series.
J Stroke Cerebrovasc Dis
December 2024
Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, United States. Electronic address:
Background: Very limited data indicate that patients with stroke from cancer-associated NBTE (Ca-NBTE) exhibit a characteristic pattern of widely distributed ischemic lesions of varying sizes.
Methods: An electronic search of Mayo Clinic records (03/31/2002-06/30/2022) with ensuing manual review of brain magnetic resonance imaging (MRI) was performed to identify topographic characteristics of stroke from Ca-NBTE.
Results: In 112 patients with Ca-NBTE, 92 (82.
Non-bacterial thrombotic endocarditis: a clinical and pathophysiological reappraisal.
Eur Heart J
November 2024
Department of Cardiology, University of Texas Health Sciences Center, MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.
Non-bacterial thrombotic endocarditis (NBTE), formerly recognized as marantic endocarditis, represents a rare cardiovascular pathology intricately linked with hypercoagulable states, notably malignancy and autoimmune disorders. Characterized by the development of sterile vegetations comprised of fibrin and platelets on cardiac valves, NBTE poses a diagnostic challenge due to its resemblance to infective endocarditis. Therapeutic endeavours primarily revolve around addressing the underlying aetiology and instituting anticoagulant regimens to forestall embolic events, with surgical intervention seldom warranted.
View Article and Find Full Text PDFCardiac calcified amorphous tumor in a patient with lung cancer.
Gen Thorac Cardiovasc Surg Cases
August 2024
Department of Cardiovascular Surgery, NHO Takasaki General Medical Center, Gunma, Japan.
Article Synopsis
- Calcified amorphous tumors of the heart are rare, non-cancerous masses made up of calcified nodules and fibrous tissue, often linked to conditions like mitral annular calcification, especially in patients with kidney issues.
- A case study of a 77-year-old woman with lung cancer revealed a tumor in her heart, which was surgically removed and identified as a calcified amorphous tumor, despite her normal kidney function.
- The findings imply that there may be a connection between calcified amorphous tumors and cancer, potentially due to alterations in blood coagulation from the malignancy.
Non-bacterial thrombotic endocarditis in long-standing primary hypoparathyroidism: A case report.
Turk Gogus Kalp Damar Cerrahisi Derg
July 2024
Department of Cardiovascular Surgery, Acıbadem Maslak Hospital, Istanbul, Türkiye.
Non-bacterial thrombotic endocarditis is a rare condition characterized by the formation of thrombotic vegetations on heart valve leaflets, leading to valvular dysfunction, heart failure and thromboembolic events. It is known to be associated with other diseases and some cases remain undiagnosed or can be diagnosed in the postmortem analysis. Surgical excision of the mass may be necessary to prevent further embolic events and other complications.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!