AI Article Synopsis
- Peripheral insulin resistance (IR) is a key risk factor for various serious health conditions, including type 2 diabetes and neurodegenerative diseases.
- Research has identified the brain as a region that responds to insulin, impacting its metabolism and function, but the exact mechanisms connecting IR and brain health are still not well understood.
- The review will explore the link between insulin resistance and Alzheimer's disease, and propose potential therapeutic strategies to prevent brain IR and its associated impacts.
Article Abstract
Peripheral insulin resistance (IR) is a well-documented, independent risk factor for the development of type 2 diabetes, cardiovascular disease, cancer and cellular senescence. Recently, the brain has also been identified as an insulin-responsive region, where insulin acts as regulator of the brain metabolism. Despite the clear link between IR and the brain, the exact mechanisms underlying this relationship remain unclear. Therapeutic intervention in patients showing symptoms of neurodegenerative diseases has produced little or no results. It has been demonstrated that insulin resistance plays a significant role in the pathogenesis of neurodegenerative diseases, particularly cognitive decline. Peripheral and brain IR may represent a modifiable state that could be used to prevent major brain disorders. In this review, we will analyse the scientific literature supporting IR as a risk factor for Alzheimer's disease and suggest some therapeutic strategies to provide a new proposal for the prevention of brain IR and its consequences.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11351221 | PMC |
| http://dx.doi.org/10.3390/biomedicines12081888 | DOI Listing |
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