AI Article Synopsis
- - Vulvar intraepithelial neoplasia (VIN) is a non-invasive lesion that can lead to squamous cell carcinoma (SCC) of the vulva and requires a biopsy for diagnosis, as there is no screening test available.
- - A case study of a 66-year-old woman with a tumor resembling a condyloma was diagnosed with VIN III after a biopsy and histological examination, confirming the presence of specific markers (p16(+) and p53(+)).
- - The case highlights the need for multidisciplinary collaboration in treatment and emphasizes the importance of lifelong monitoring since removing lesions does not prevent the development of invasive cancer.
Article Abstract
Vulvar intraepithelial neoplasia, also known as VIN, is a non-invasive squamous lesion and precursor of squamous cell carcinoma (SCC) of the vulva. There is no screening test for vulvar intraepithelial neoplasia. Diagnosis of VIN is made clinically and confirmed with a biopsy. We describe a 66-year-old woman with a condyloma-like tumour located in the skin on the vestibule of the vagina. A biopsy sample was taken from the nodule. The definitive diagnosis is supported by the histological examination (VIN III) and immunohistochemical examination of p16(+), p53(+), and a few cell nuclei. The case provides information on the importance of multidisciplinary cooperation. Lifelong surveillance is essential since the resection of individual lesions does not guarantee the prevention of invasive cancer.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11351730 | PMC |
| http://dx.doi.org/10.3390/biomedicines12081799 | DOI Listing |
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