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A High-Carbohydrate Diet Induces Cognitive Impairment and Promotes Amyloid Burden and Tau Phosphorylation via PI3K/Akt/GSK-3β Pathway in db/db Mice. | LitMetric

AI Article Synopsis

  • Cognitive impairment is common in type 2 diabetes and influenced by dietary patterns, especially the effects of high-carbohydrate diets (HCDs) on cognitive function, which are still not fully understood.
  • A study on diabetic and wild-type mice found that HCDs worsened cognitive decline in diabetic mice, increasing the burden of amyloid-β, promoting tau protein phosphorylation, and causing neuroinflammation.
  • The research suggests that a high carbohydrate intake negatively affects cognitive function in diabetes, although the damages are less severe compared to those from high-fat diets.

Article Abstract

Background: Cognitive impairment is a prevalent complication of type 2 diabetes, influenced significantly by various dietary patterns. High-carbohydrate diets (HCDs) are commonly consumed nowadays; however, the specific impact of HCDs on cognitive function in diabetes remains unclear.

Methods: The objective of this study was to investigate whether an HCD has effects on cognition in diabetes. Eight-week-old diabetic (db/db) mice and wild-type (WT) mice underwent a twelve-week dietary intervention, including a normal diet (ND), an HCD, or a high-fat diet (HFD). Following this, behavioral tests were conducted, and related hippocampal pathology was evaluated.

Results: Our results demonstrated that an HCD exacerbated cognitive decline in db/db mice compared to an ND. Additionally, an HCD increased amyloid-β burden and expression of β-site APP cleaving enzyme-1. An HCD was also found to promote the phosphorylation of tau protein via the PI3K/Akt/GSK-3β pathway. Furthermore, an HCD markedly induced neuroinflammation and increased the quantity of microglia and astrocytes. However, these damages induced by an HCD were less severe than those caused by an HFD.

Conclusions: Collectively, our findings indicate that a high intake of carbohydrates can have an adverse impact on cognitive function in diabetes.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11351503PMC
http://dx.doi.org/10.3390/biomedicines12081701DOI Listing

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