AI Article Synopsis
- - Orofacial clefts (OFCs) are the second most prevalent birth defect globally, caused by a mix of genetic and environmental factors.
- - The study analyzed the relationship between specific genetic variants (SNPs) and non-syndromic OFCs in a Polish sample of 209 affected individuals and 418 healthy controls.
- - A significant link was found between the rs7078 SNP and the likelihood of OFCs, while other SNPs (rs1081131, rs13041247, rs3769817) showed no significant correlation.
Article Abstract
Orofacial clefts (OFCs) are the second most common birth defect worldwide. The etiology of OFCs involves complex interactions between genetics and environment. Advances in genomic technologies have identified gene variants associated with OFCs. This study aimed to investigate whether selected SNPs in the , , , and genes influence the occurrence of non-syndromic OFCs in the Polish population. The study included 209 individuals with non-syndromic OFCs and 418 healthy controls. Saliva and umbilical cord blood samples were collected for DNA extraction. Four SNPs in the , , , and genes were genotyped using real-time PCR-based TaqMan assays. Statistical analysis was performed using logistic regression to assess the association between SNPs and OFCs. A significant association was found between the rs7078 CC polymorphism and OFCs (OR = 3.22, CI 1.68-6.17, < 0.001). No significant associations were identified for the rs1081131, rs13041247, and rs3769817 polymorphisms. The research indicates that the rs7078 polymorphism significantly influences the occurrence of orofacial cleft palate in the Polish population, whereas the rs3769817, rs1801131, and rs13041247 SNPs do not show such a correlation.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11351639 | PMC |
| http://dx.doi.org/10.3390/biomedicines12081700 | DOI Listing |
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