AI Article Synopsis
- Obesity is a complex condition influenced by various genetic and environmental factors, including diet and intestinal microbes.
- The role of intestinal microbes and their metabolites is significant in regulating energy metabolism and inflammation, and they also affect how genes are expressed through epigenetic modifications like DNA methylation.
- Recent research highlights the interactions between intestinal microbiota and epigenetics, providing new insights for understanding, preventing, and treating obesity.
Article Abstract
Obesity is a multifactorial chronic inflammatory metabolic disorder, with pathogenesis influenced by genetic and non-genetic factors such as environment and diet. Intestinal microbes and their metabolites play significant roles in the occurrence and development of obesity by regulating energy metabolism, inducing chronic inflammation, and impacting intestinal hormone secretion. Epigenetics, which involves the regulation of host gene expression without changing the nucleotide sequence, provides an exact direction for us to understand how the environment, lifestyle factors, and other risk factors contribute to obesity. DNA methylation, as the most common epigenetic modification, is involved in the pathogenesis of various metabolic diseases. The epigenetic modification of the host is induced or regulated by the intestinal microbiota and their metabolites, linking the dynamic interaction between the microbiota and the host genome. In this review, we examined recent advancements in research, focusing on the involvement of intestinal microbiota and DNA methylation in the etiology and progression of obesity, as well as potential interactions between the two factors, providing novel perspectives and avenues for further elucidating the pathogenesis, prevention, and treatment of obesity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11351752 | PMC |
| http://dx.doi.org/10.3390/biomedicines12081633 | DOI Listing |
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