AI Article Synopsis
- N6-methyladenosine (m6A) is an important RNA modification that plays a significant role in the development of skeletal muscle, with Rhein being an anti-inflammatory extract that impacts the metabolism of m6A by inhibiting key demethylases.
- During muscle fiber formation and after muscle injury, changes in the expression of specific genes and m6A levels were observed, indicating a complex relationship between gene activity and RNA modification in muscle repair.
- Rhein's inhibition of m6A demethylation was found to reduce key muscle markers and hinder muscle regeneration in a mouse model, suggesting it may have potential therapeutic uses for improving muscle recovery after injury.
Article Abstract
N6-methyladenosine (m6A) is a crucial RNA modification affecting skeletal muscle development. Rhein, an anti-inflammatory extract, inhibits , a key demethylase in m6A metabolism. Our study showed that during muscle fiber formation, and expression increased while m6A levels decreased. After muscle injury, and expression initially rose but later fell, while m6A levels initially dropped and then recovered. Inhibition of by Rhein reduced MyHC and expression, indicating myoblast differentiation suppression. In a mouse model, Rhein decreased MyHC expression and muscle fiber cross-sectional area, delaying muscle regeneration. Rhein's ability to increase RNA m6A modification delays skeletal muscle remodeling post-injury, suggesting a new medicinal application for this plant extract.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11350746 | PMC |
| http://dx.doi.org/10.3390/ani14162434 | DOI Listing |
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