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Emerging interactions between mitochondria and NAD metabolism in cardiometabolic diseases. | LitMetric
Nicotinamide adenine dinucleotide (NAD) is an essential coenzyme for redox reactions and regulates cellular catabolic pathways. An intertwined relationship exists between NAD and mitochondria, with consequences for mitochondrial function. Dysregulation in NAD homeostasis can lead to impaired energetics and increased oxidative stress, contributing to the pathogenesis of cardiometabolic diseases. In this review, we explore how disruptions in NAD homeostasis impact mitochondrial function in various cardiometabolic diseases. We discuss emerging studies demonstrating that enhancing NAD synthesis or inhibiting its consumption can ameliorate complications of this family of pathological conditions. Additionally, we highlight the potential role and therapeutic promise of mitochondrial NAD transporters in regulating cellular and mitochondrial NAD homeostasis.
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cardiometabolic diseases
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