AI Article Synopsis

  • Cholic acid-based biodegradable reverse polymeric micelles were developed as a drug delivery system for poorly soluble drugs, specifically through the synthesis of N-acetylcysteine functionalized triarmed poly (Dl-lactide) known as ACyCA-triarmed (DLL).
  • The micelles were characterized using various techniques like GPC and FT-IR, and their critical micellar concentration was determined to be 1.99 mg/mL.
  • The research also demonstrated that these reverse micelles could encapsulate gold nanoparticles (AuNPs) with improved antimicrobial and antioxidant properties, making them a promising platform for slow, sustained drug release of hydrophobic drugs such as doxorubicin.

Article Abstract

Cholic acid based biodegradable reverse polymeric micelles have been widely utilized as preclinically suitable drug delivery system for poorly water-soluble drugs. In this report, we developed N-acetylcysteine functionalized cholic acid based triarmed poly (Dl-lactide) (ACyCA-triarmed (DLL) as reversed polymeric micelles for drug delivery studies. ACyCA was synthesized via thiol-yne click reaction and subsequently used as an initiator for the synthesis of ACyCA-triarmed (DLL) through ring opening polymerization (ROP) using Sn (Oct) as a catalyst. The synthesized ACyCA-triarmed (DLL) was characterized using GPC, FT-IR, H NMR, C NMR, spectrofluorometer, HR-TEM, DSC, TGA, XRD, DLS, and zeta potential techniques. The reverse critical micellar concentration of the polymer was determined to be 1.99 mg/mL using a spectrofluorometer. The synthesized reverse micelles (RMs) were utilized as a reducing and capping agent for the preparation of AuNPs under sunlight exposure. The formed AuNPs exhibited spherical in shape with an average size of ∼ 23.4 nm and D was found to be 86.8 ± 1.3 nm as evidenced by the TEM and DLS analysis. Furthermore, the antimicrobial activity, hemolytic activity, anti-oxidant activity, and in-vitro drug release studies were examined for the RMs-AuNPs and compared with RMs. The hydrophobic nature of RMs and RMs-AuNPs had better haemocompatibility at above the reversed CMC. The antioxidant activity RMs-AuNPs showed better inhibitory effect in a dose-dependent manner as compared to RMs. The RMs-AuNPs formulation act as reservoir for solubilization of hydrophobic doxorubicin (Dox.HCl) drugs and can be used as therapeutic platform for slow and sustained release of drugs in biological medium.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijbiomac.2024.135085DOI Listing

Publication Analysis

Top Keywords

cholic acid
12
acid based
12
drug delivery
12
acyca-triarmed dll
12
n-acetylcysteine functionalized
8
functionalized cholic
8
based triarmed
8
triarmed poly
8
poly dl-lactide
8
antimicrobial activity
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!