From a physiological perspective, the delineation between steady-state and non-steady-state exercise, also referred to as the maximal metabolic steady state, holds paramount importance for evaluating athletic performance and designing and monitoring training programs. The critical power and the maximal lactate steady state are two widely used indices to estimate this threshold, yet previous studies consistently reported significant discrepancies between their associated power outputs. These findings have fueled the debate regarding the interchangeability of critical power and the maximal lactate steady state in practice. This paper reviews the methodological intricacies intrinsic to the determination of these thresholds, and elucidates how inappropriate determination methods and methodological inconsistencies between studies have contributed to the documented differences in the literature. Through a critical examination of relevant literature and by integration of our laboratory data, we demonstrate that differences between critical power and the maximal lactate steady state may be reconciled to only a few Watts when applying appropriate and strict determination criteria, so that both indices may be used to estimate the maximal metabolic steady-state threshold in practice. To this end, we have defined a set of good practice guidelines to assist scientists and coaches in obtaining the most valid critical power and maximal lactate steady state estimates.
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http://dx.doi.org/10.1007/s40279-024-02075-4 | DOI Listing |
J Antimicrob Chemother
December 2024
Pharmacy Department, Hospital del Mar, Barcelona, Spain.
Objectives: To describe the pharmacokinetics (PK) of linezolid in plasma and pleural fluid (PF) in critically ill patients with proven or suspected Gram-positive bacterial infections.
Patients And Methods: Observational PK study in 14 critically ill patients treated with linezolid at standard doses. Blood and PF samples were collected and analysed by HPLC.
Front Neurosci
December 2024
Department of Rehabilitation Medicine, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Background: Vagus nerve stimulation (VNS) has emerged as a promising therapeutic approach for stroke treatment, drawing significant attention due to its potential benefits. However, despite this growing interest, a systematic bibliometric analysis of the research landscape is yet to be conducted.
Methods: We performed a comprehensive search of the Web of Science Core Collection (WoSCC) database for literature published between January 1, 2005, and August 31, 2024.
ACS Catal
December 2024
Departments of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, United States.
The 3-chymotrypsin-like protease (3CL-PR; also known as Main protease) of SARS-CoV-2 is a cysteine protease that is the target of the COVID-19 drug, Paxlovid. Here, we report for 3CL-PR, the pH-rate profiles of a substrate, an inhibitor, affinity agents, and solvent kinetic isotope effects (sKIEs) obtained under both steady-state and pre-steady-state conditions. "Bell-shaped" plots of log( / ) vs pH for the substrate (Abz)SAVLQ*SGFRK(Dnp)-NH and p vs pH for a peptide aldehyde inhibitor demonstrated that essential acidic and basic groups of p = 8.
View Article and Find Full Text PDFFront Neurol
December 2024
Nantong Fourth People's Hospital, Nantong, China.
Background: Essential tremor (ET) is one of the most prevalent neurodegenerative disorders, with surgery serving as the principal treatment option. This paper presents a bibliometric analysis of research in the field of ET surgery from 2004 to 2024, aiming to identify current research hotspots and inform future research directions.
Methods: This study employs CiteSpace to analyze publication trends, countries/institutions, authors, keywords, and co-cited references in ET surgery, using the Web of Science core database from 2004 to 2024 to delineate the research pathways.
Vis Neurosci
December 2024
Department of Psychology to Division of Psychology, University of Stirling, Stirling, UK.
Sparse coding theories suggest that the visual brain is optimized to encode natural visual stimuli to minimize metabolic cost. It is thought that images that do not have the same statistical properties as natural images are unable to be coded efficiently and result in visual discomfort. Conversely, artworks are thought to be even more efficiently processed compared to natural images and so are esthetically pleasing.
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