Inflammatory aspects of Alzheimer's disease.

Acta Neuropathol

Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 6, Avenue du Swing, Belvaux, L-4367, Esch-Belval, Luxembourg.

Published: August 2024

AI Article Synopsis

  • Alzheimer’s disease (AD) is the most common chronic neurodegenerative disorder, marked by cognitive decline and memory loss primarily due to neurodegeneration.
  • Recent research is focusing on neuroinflammation, particularly the roles of microglia and astrocytes, in the progression of AD and its core pathologies, such as amyloid beta and tau tangles.
  • The article emphasizes the need to explore various cellular contributors to neuroinflammation to inform new treatment strategies for AD.

Article Abstract

Alzheimer´s disease (AD) stands out as the most common chronic neurodegenerative disorder. AD is characterized by progressive cognitive decline and memory loss, with neurodegeneration as its primary pathological feature. The role of neuroinflammation in the disease course has become a focus of intense research. While microglia, the brain's resident macrophages, have been pivotal to study central immune inflammation, recent evidence underscores the contributions of other cellular entities to the neuroinflammatory process. In this article, we review the inflammatory role of microglia and astrocytes, focusing on their interactions with AD's core pathologies, amyloid beta deposition, and tau tangle formation. Additionally, we also discuss how different modes of regulated cell death in AD may impact the chronic neuroinflammatory environment. This review aims to highlight the evolving landscape of neuroinflammatory research in AD and underscores the importance of considering multiple cellular contributors when developing new therapeutic strategies.

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Source
http://dx.doi.org/10.1007/s00401-024-02790-2DOI Listing

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