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Skin Rejuvenation Using Autologous Cultured Fibroblast Grafting.
Cureus
December 2024
Plastic and Reconstructive Surgery, St. Marianna University School of Medicine, Kawasaki, JPN.
Background: Recently, autologous cultured fibroblast and platelet-rich plasma (PRP) therapies have been attempted for skin rejuvenation. Unlike PRP, grafted fibroblasts not only produce connective tissue but also influence the surrounding environment through a paracrine effect. Fibroblast-derived cytokines interact with and are modulated by neighboring tissue-constituting cells.
View Article and Find Full Text PDFUnusual salt effects on the time-dependent behavior of charge and shape anisotropic hectorite clay gels: Role of electric double layer (EDL) repulsive force.
J Chem Phys
December 2024
Department of Chemical Engineering, University of Western Australia, Crawley 6009, Australia and Centre for Microscopy, Characterization and Analysis, University of Western Australia, Crawley 6009, Australia.
Salt strengthened the bond formed and quickened the bonding process of 3-5 wt. % hectorite gels during the structural rejuvenation process. This even occurred at 0.
View Article and Find Full Text PDFUnlabelled: Hematopoietic stem cells (HSCs) responsible for blood cell production and their bone marrow regulatory niches undergo age-related changes, impacting immune responses and predisposing individuals to hematologic malignancies. Here, we show that the age-related alterations of the megakaryocytic niche and associated downregulation of Platelet Factor 4 (PF4) are pivotal mechanisms driving HSC aging. PF4-deficient mice display several phenotypes reminiscent of accelerated HSC aging, including lymphopenia, increased myeloid output, and DNA damage, mimicking physiologically aged HSCs.
View Article and Find Full Text PDFIntroduction: Microneedling, a technique involving controlled dermal microwounding, and platelet-rich plasma (PRP) injections are both employed for skin rejuvenation. While both treatments individually show promise, limited research has explored their combined efficacy. This study aimed to evaluate the effectiveness of combining PRP injections with microneedling for aesthetic concerns around the eyes under standardized conditions.
View Article and Find Full Text PDFTherapeutic Potential of Extracellular Vesicles (Exosomes) Derived From Platelet-Rich Plasma: A Literature Review.
J Cosmet Dermatol
December 2024
School of Pharmacy, BRAC University, Dhaka, Bangladesh.
Background: There are exciting advances in the field of exosomes research as a potential regenerative therapy. Platelet-rich plasma represents an abundant source of exosomes.
Aim: To present evidence on the use of platelet-rich plasma-derived exosomes in dermatology and discuss current technical limitations.
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