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Anti-Scar Effects of Micropatterned Hydrogel after Glaucoma Drainage Device Implantation.
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January 2025
Department of Ophthalmology, The Future Medicine Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, People's Republic of China.
Excessive fibrosis is the primary factor for the failure of glaucoma drainage device (GDD) implantation. Thus, strategies to suppress scar formation in GDD implantation are crucial. Although it is known that in implanted medical devices, microscale modification of the implant surface can modulate cell behavior and reduce the incidence of fibrosis, in the field of ophthalmic implants, especially the modification and effects of hydrogel micropatterns have rarely been reported.
View Article and Find Full Text PDFBioactive Glasses: Advancing Skin Tissue Repair through Multifunctional Mechanisms and Innovations.
Biomater Res
January 2025
Department of Burn and Plastic Surgery, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou 215006, China.
As a complex and dynamically regulated process, wound healing is collaboratively carried out by multiple types of cells. However, the precise mechanisms by which these cells contribute to immune regulation are not yet fully understood. Although research on bone regeneration has been quite extensive, the application of bioactive glass (BG) in skin tissue repair remains still relatively underexplored.
View Article and Find Full Text PDFOrchestrated response from heterogenous fibroblast subsets contributes to repair from surgery-induced stress after airway reconstruction.
JCI Insight
January 2025
Department of Otolaryngology, Nationwide Children's Hospital, Columbus, United States of America.
Surgery of the tracheobronchial tree carries high morbidity, with over half of the complications occurring at the anastomosis. Although fibroblasts are crucial in airway wound healing, the underlying cellular and molecular mechanisms in airway reconstruction remain unknown. We hypothesized that airway reconstruction initiates a surgery-induced stress (SIS) response, altering fibroblast communication within airway tissues.
View Article and Find Full Text PDFPlumbagin improves myocardial fibrosis after myocardial infarction by inhibiting the AKT/mTOR pathway to upregulate autophagy levels.
Int Immunopharmacol
January 2025
Department of Cardiovascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, People's Republic of China. Electronic address:
Cardiac fibrosis is a chronic inflammatory response that considerably impacts cardiac function following myocardial infarction (MI). Although Plumbagin, a natural compound, has been shown to have anti-fibrotic effects by suppresses the ROS and NF-κB pathways in liver fibrosis, its role in regulating cardiac function and cardiac fibrosis post-MI remains unknown. In this study, we demonstrate that Plumbagin effectively inhibits TGF-β1-induced myocardial fibroblast fibrosis and promotes autophagy activation by suppressing the AKT/mTOR pathway.
View Article and Find Full Text PDFBacteria in hypertrophic scars promote scar formation through HSBP1-mediated autophagy.
Wound Repair Regen
January 2025
Department of Burn, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Bacterial colonisation in hypertrophic scars (HSs) has been reported, yet the precise mechanism of their contribution to scar formation remains elusive. To address this, we examined HS and normal skin (NS) tissues through Gram staining and immunofluorescence. We co-cultured fibroblasts with heat-inactivated Staphylococcus aureus (S.
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