AI Article Synopsis
- The functioning of neural circuits is crucial for adapting to environmental changes, and various molecules, including neurotransmitters and amino acids, modulate neuronal activity.
- Researchers investigated the role of an amino acid transporter (MND) in neurons of the adult brain and found it expressed in mushroom body neurons and glial cells.
- Live calcium imaging revealed that MND is critical for the sensitivity of certain neurons to specific L-amino acids and that the TOR pathway, rather than the GDH pathway, is involved in their Leucine-dependent responses.
Article Abstract
The proper functioning of neural circuits that integrate sensory signals is essential for individual adaptation to an ever-changing environment. Many molecules can modulate neuronal activity, including neurotransmitters, receptors, and even amino acids. Here, we ask whether amino acid transporters expressed by neurons can influence neuronal activity. We found that (), which encodes a light chain of a heterodimeric amino acid transporter, is expressed in different cell types of the adult brain: in mushroom body neurons (MBs) and in glial cells. Using live calcium imaging, we found that MND expressed in α/β MB neurons is essential for sensitivity to the L-amino acids: Leu, Ile, Asp, Glu, Lys, Thr, and Arg. We found that the Target Of Rapamycin (TOR) pathway but not the Glutamate Dehydrogenase (GDH) pathway is involved in the Leucine-dependent response of α/β MB neurons. This study strongly supports the key role of MND in regulating MB activity in response to amino acids.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11352668 | PMC |
| http://dx.doi.org/10.3390/cells13161340 | DOI Listing |
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