AI Article Synopsis
- The study explored ACE2 expression levels in different ocular glands using male C57BL/6J mice, finding the highest levels in the Meibomian glands.
- Researchers confirmed that ACE2 directly binds to the S protein using co-immunoprecipitation assays in the ocular surface epithelia.
- S protein treatment led to increased inflammation, CD45+ cell infiltration, and notable cell apoptosis in both the ocular surface epithelial cells and Meibomian glands.
Article Abstract
The aim of the study was to investigate the expression levels of ACE2 in ocular glands and to investigate the effect of S protein on them. Male C57BL/6J mice were used for the experiments. The expression levels of ACE2 are highest in the Meibomian glands, followed by the conjunctiva, the cornea, and the lacrimal glands. Co-immunoprecipitation assays confirmed direct binding between ACE2 and S protein in ocular surface epithelia and Meibomian glands. CD45+ cell infiltration was found in the S protein treatment group, which was accompanied by upregulation of inflammation-related cytokines. There was also prominent cell apoptosis in the S protein treatment group. In conclusion, not only the cornea and the conjunctiva, but also the Meibomian glands express ACE2, and S protein could induce ocular surface epithelial cell and Meibomian gland cell inflammation and apoptosis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11353300 | PMC |
| http://dx.doi.org/10.3390/diseases12080169 | DOI Listing |
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