AI Article Synopsis
- Previous studies have focused on the link between obesity and genetics, but there's limited research on how these factors affect long-term changes in body mass index (BMI).
- Data from 1,030 cases in the Korean Genome and Epidemiology Study (2000-2014) revealed significant genetic influences on BMI changes, analyzing data from 3,074 participants.
- The findings identified specific genes related to type 2 diabetes, cardiovascular issues, and other metabolic pathways, indicating that genetics play a role in BMI changes among Korean adults and contribute to obesity risk.
Article Abstract
Although previous studies have examined the relationship between obesity and genetics in response to the growing obesity epidemic, research on the relationship between obesity and long-term changes in body mass index (BMI) is limited. To investigate this relationship, data from 1030 cases in the Anseong and Ansan cohorts were collected from the Korean Genome and Epidemiology Study conducted by the Korea National Institute of Health between 2000 and 2014. Cases lacking participants' BMI data throughout the study were excluded, resulting in a final sample size of 3074. An increase or decrease in BMI was analyzed using PLINK, STRING, and DAVID, with significant differences observed in the , , , , , , , , and genes. These genes were observed to cluster with pathways related to type 2 diabetes, cardiovascular disease, metabolic processes, and endocytosis-related genes. These results suggest that several genes are involved in BMI changes and that several pathways are associated with obesity risk. Moreover, some genetic variants appear to influence BMI changes in Korean adults.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11352382 | PMC |
| http://dx.doi.org/10.3390/cimb46080536 | DOI Listing |
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